3 edition of Clinical application of interferons and their inducers found in the catalog.
|Other titles||Interferon and interferon inducers, clinical applications.|
|Statement||edited by Dale A. Stringfellow.|
|Series||Clinical pharmacology ;, v. 3|
|Contributions||Stringfellow, Dale A., 1944-|
|LC Classifications||QR187.5 .C55 1986|
|The Physical Object|
|Pagination||xii, 277 p. :|
|Number of Pages||277|
|LC Control Number||86004598|
Interferons ά and β bind to the same receptor, which is composed of two subunits The binding of either interferon- ά or interferon- β to this receptor results in the activation of Janus tyrosine kinases Jak1 and Tyk2, which results in the phosphorylation of signal transducers and activators of transcription 1 and 2. This review describes a long-standing experience of screening for interferon (IFN) inducers in Russia. IFN inducers represent a special group of potential antiviral compounds. The main requirements for them are (1) high IFN-inducing activity, (2) absence of side effects, (3) wide spectrum of antimicrobial activity, (4) broad therapeutic Cited by:
Interferon Interferon and Interferon Inducers. Clinical Applications. DALE A. STRINGFELLOW, Ed. Dekker, NewYork, xii, pp., illus. $ Modem Pharmacology-Toxicology, vol. The first flowering ofinterferon stud-ies occurred in the late '50's and early '60's. Duringthis time the basic biologi-cal properties ofinterferons were eluci-. Interferons: Mechanisms of action and clinical applications Article Literature Review in Current Opinion in Oncology 15(6) December .
The first report on the antitumor effects of interferon α/β (IFN-I) in mice was published 50 years ago. IFN-α were the first immunotherapeutic drugs approved by the FDA for clinical use in cancer. However, their clinical use occurred at a time when most of their mechanisms of action were still unknown. These cytokines were being used as either conventional cytostatic drugs Author: Eleonora Aricò, Luciano Castiello, Imerio Capone, Lucia Gabriele, Filippo Belardelli. research toward its clinical application. This article is a revised English version of a paper originally published in the Journal of the Japan Medical Association (Vol. , No. 7, , pages –). Types and Properties Interferon (IFN) is generally classiﬁed into 3 types (Table 1). First, IFN- is produced whenFile Size: 50KB.
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Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (K), or click on a page image below to browse page by : J.B.
Derbyshire. Clinical application of interferons and their inducers. New York: Dekker, © (OCoLC) Online version: Clinical application of interferons and their inducers. New York: Dekker, © (OCoLC) Document Type: Book: All Authors / Contributors: Dale A Stringfellow.
Both the mUltiple actions of interferons (a virtual cascade of biochemical reactions may be induced, as documented herein) and the high visibility of interferon research provided by the millions of dollars invested both by national health agencies and by multinational pharmaceutical companies, contributed to an upsweep in public attention to drug development probably.
CLINICAL APPLICATION OF INTERFERONS AND THEIR INDUCERS. SECOND EDITION. (PMCID:PMC) Full Text Citations ; BioEntities ; Related Articles ; External Links ; Can J Vet Res. July; 52(3): PMCID: PMC CLINICAL APPLICATION OF INTERFERONS AND THEIR INDUCERS.
SECOND EDITION. Tumor and Virus-Infected Cells.- G. Effects of Interferon and Its Inducers on Natural Killer Cell Activity.- I. Discovery and Possible Roles of NK Cells.- II.
Mouse NK Cell Activity.- III. Human NK Cell Activity.- H. Summary and Concluding Comments.- References.- 21 Clinical Use of Interferons: Localized Application in Viral Diseases With 3.
A double blind trial was begun on patients with active and quiescent disease. The quiescent group was treated with poly (I)'poly (C) or methyl cellulose, the active group with Experience with clinical applications of interferon and interferon inducers poly (l)'poly (C) Cited by: (Second of Three Parts) Properties of Interferon Cells from several different classes of animals, including teleost fishes, have been shown to produce interferon Cited by: Carter WA, Horoszewicz JS () Human interferon and its inducers: clinical program overview at Roswell Park Memorial Institute.
Cancer Treat Rep – PubMed Google Scholar Carter WA, Pitha PM, Marshall LW, Tazawa I, Tazawa S, Ts’o POP () Structural requirements of then I rC complex for induction of human by: 9.
The first road block in their clinical application was the finding that the interferons were species specific in their biological activity. With a few rare exceptions, only human or primate interferons are active in human cells, so the single source of interferons for human use in the s and 70s seemed to be primate cells, and the expertise necessary to Cited by: Moreover, there are certain limitations in the clinical usefulness of interferon inducers including a relatively high degree of toxicity and low therapeutic index, hyporeactivity to repeated induction, and potential antibody formation against the inducer by: 1.
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The use of interferons and interferon inducers to treat human viral and neoplastic diseases is currently under intensive investigation. Considerable. Interferons, Interferon Inducers, and Interferon-Ribavirin in Treatment of Flavivirus-Induced Encephalitis in Mice Pieter Leyssen, 1 Christian Drosten, 2 Marcus Paning, 2 Nathalie Charlier, 1 Jan Paeshuyse, 1 Erik De Clercq, 1 and Johan Neyts 1, *Cited by: At long last, the first book to cover all important areas of interferon science in one volume.
Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications. Edited by an experienced interferonologist.
The book opens with a chapter that comprehensively reviews the antiviral effects of extracellular double-stranded RNA, the viral toxin. This is followed by chapters that review the properties of type I and type III interferons, and the role of interferon-stimulated genes.
The next five chapters are devoted to understanding the diverse strategies used by clinically relevant human viruses.
Immune Interferon: Properties and Clinical Applications is essential reading for anyone working with interferons. Having developed their own brand of interferon-gamma, the authors have become well known for their research and significant contributions in the fields of molecular biology, biochemistry, and interferon-gamma.
Handbook of Experimental Pharmacology, Continuation of Handbuch der experimentellen Pharmakologie, Today, the basic mood of researchers and clinical investigators, both at the center and on the periphery of interferon studies, is optimistic regarding the future of interferons as therapeutic substances.
Meaning of Interferon 2. Discovery of Interferon 3. Classes 4. Mechanism of Action 5. Receptors and Signal Transduction 6. Role 7. Commercial Production 8. Clinical Applications.
Meaning of Interferon: Interferons (INF) are produced by human and animal cells in minute quantities mainly in response to viral infections, and help eliminate such. Author(s): Stringfellow,Dale A, Title(s): Clinical application of interferons and their inducers/ edited by Dale A.
Stringfellow. Edition: 2nd ed. Country of Publication: United States Publisher: New York: Dekker, c Additional Physical Format: Online version: Interferon and interferon inducers, clinical applications. New York: M. Dekker, © (OCoLC). Interferon has two well defined effects. It inhibits the replication of viruses and it suppresses cell division.
Despite the potential importance of both these properties in medicine, surprisingly little clinical use has yet been made of interferon, one reason being the great difficulty in obtaining sufficient human interferon for experimental by: 6.Stringfellow, Clinical Applications of Interferon and Their Inducers, 2nd ed () Marcel Dekker New York 8.
D.J. Winston, L.J. Eron, M. Ho, Recombinant interferon alpha-2a for treatment of herpes zoster in immunosuppressed patients with cancer Am J Med () Cited by: In: Stringellow DA (ed) Interferon and interferon inducers: clinical applications.
Dekker, New York, pp – Google Scholar Wierenga W, Skulnick HI, Stringfellow DA, Weed SD, Renis HE, Eidson EE () 5-Substituted 2-aminophenyl-4(3H) by: 7.